Figure 8: Effect of SD1 treatment on nucleoid morphology of Mtb.
From: Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors
(a) Fluorescent micrograph of Mtb cells showing DAPI-stained condensed nucleoid in untreated cells (top) and dispersed nucleoid (bottom) in SD1 treated cells. Scale bar, 1 μm. (b) Transmission electron micrographs of untreated Mtb cells (left) with confined bi-lobular nucleoid (arrows), and of SD1-treated cells (right) with nucleoid spread along the cell length displaying the lack of compactness. Scale bar, 0.5 μm.
