Figure 1: Pathways of (glycero)phospholipid biosynthesis in mammalian cells. | Nature Communications

Figure 1: Pathways of (glycero)phospholipid biosynthesis in mammalian cells.

From: X-ray structure of a CDP-alcohol phosphatidyltransferase membrane enzyme and insights into its catalytic mechanism

Figure 1

The biosynthesis starts either from diacylglycerol (DAG) or phosphatidic acid (PA), and results in production of phosphatidylcholine (PC), phosphatidyletanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI) and cardiolipin (CL), adapted from Hermansson et al.7 The intermediate metabolites are CDP-DAG, phosphatidylglycerol phosphate (PGP) and phosphatidylglycerol (PG). The CDP-alcohol phosphatidyltransferase family enzymes in human are highlighted; CPT, cholinephosphotransferase 1; CEPT, choline/ethanolaminephosphotransferase 1; EPT, ethanolaminephosphotransferase 1; CDIPT, phosphatidylinositol synthase 1; and CLS, cardiolipin synthase.

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