Figure 3: X-ray structure of IPCT/DIPPS.

The protein is dimerized via the TM domain. (a) One protomer is rainbow coloured and the other protomer (related by crystallographic symmetry) is in blue for cytoplasmic IPCT domain and grey for membrane DIPPS domain. Red arrows indicate the access to their active sites with a putative Mg2+ drawn as a cyan sphere. Membrane surface position (grey) was calculated with PPM server49. (b) Top view of DIPPS domain (perpendicular to the membrane plane).