Table 2 Ageing-associated phenotypes in wt and nfkb1−/− mice.

From: Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

Phenotype

nfkb1 −/− (36 weeks)

wt (36 weeks)

wt (104 weeks)

wt (132 weeks)

Low coat quality score*

8/14

0/15

7/12

4/6

Low body condition score†

13/14

3/15

9/12

5/6

Low welfare status score‡

7/14

0/15

9/12

4/6

Ataxia

1/14

1/15

3/12

3/6

kyphosis

0/9

0/15

0/12

0/6

sarcopenia§

0/6

0/6

2/6

4/4

Terminal weight loss||

3/8

0/24

6/19

8/9

Low total body fat

6/6

0/5

0/5

4/5

Low subcutaneous fat#

5/6

0/5

3/7

5/5

Cardiac hypertrophy**

3/6

0/5

0/6

4/5

Liver: lipofuscin

2/3

1/8

1/4

6/6

Liver: karyomegaly††

4/5

1/5

3/3

3/3

Brain: lipofuscin

2/5

0/7

n.d.

4/4

Macroscopic tumours

0/6

0/7

3/7

7/11

death

6/23

0/52

15/52

34/52

  1. Data are no. of animals showing the phenotype/no. of animals observed.
  2. *Alopecia, hair greying, piloerection, fur roughness scored at a scale from 1 to 10, scores below 7 are counted as low.
  3. †Body condition67 scored at a scale from 1 to 10, scores below 7 are counted as low.
  4. ‡Physical, physiological and psychological status scored according to Hawkins et al.68 at a scale from 1 to 10, scores below 7 are counted as low.
  5. §Mean hind leg muscle fibre diameter <36 μm
  6. ||Weight >3 g below max for >1 month
  7. Total body fat=Sum (inguinal+epidymal+perirenal+mesenteric) <5% of BW
  8. #Subcutaneous fat <0.7 g
  9. **Heart mass >0.55% of BW
  10. ††>10% of hepatocyte nuclei
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