Figure 4: In vivo antitumour activity evaluation of 1P. | Nature Communications

Figure 4: In vivo antitumour activity evaluation of 1P.

From: Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy

Figure 4

(a) In vivo tumour growth inhibition curves for PBS, Zn Control, free cisplatin and 1P on the s.c. C26 tumour model. Cisplatin (dose, 3 mg kg−1) and 1P (dose, 0.75 or 0.5 mg kg−1) were administered on day 0, 3, 6. (b) Kaplan–Meier plots showing the percentage of animals remaining in the study with the s.c. C26 tumour model. (c) In vivo tumour growth inhibition curves for PBS, Zn Control, free cisplatin and 1P on the s.c. H460 tumour model. Cisplatin (dose, 3 mg kg−1) and 1P (dose, 0.5 mg kg−1) were administered on day 0, 3 and 6. Data are expressed as means±s.e.m. (n=6–8), *P<0.05, **P<0.01, ***P<0.001. (d) Photos of resected H460 tumours from various groups. From top to bottom: PBS, Zn Control, free cisplatin and 1P.

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