Figure 5: Alteration in MICB expression affects killing by NK cells.
From: RNA-binding proteins regulate the expression of the immune activating ligand MICB
(a–f) [35S]methionine-labelled cells transduced with the indicated vectors (either shRNA (a–c), or the specific RBP (d–f), x axis) were incubated for 5 h with bulk primary NK cells, and then killing levels were assessed. Data are the summation total of six independent experiments (by three donors). (a–c) Target cells transduced with a control-shRNA were used as a control and their killing levels were set to 1. Shown is the relative average killing±s.d. of three independent experiments. *P<0.005, by paired Student's t-test. (d–f) Target cells transduced with STAU2 were used as a control and their killing levels were set to 1. Shown is the relative average killing±s.d. of three independent experiments. *P<0.005, by paired Student's t-test.
