Figure 7: Proposed role of Sema3E/PlexinD1 in CR cells migration.

(a) Cross-sectional diagrams illustrating the pattern of expression of Sema3E, PlexinD1, CXCL12 and CXCR4 in neural elements at E12.5. (b,c) Diagrams illustrating the location of CR cells in dorsomedial cortex (b,c) with functional Sema3E/PlexinD1 signalling (b) and in absence of Sema3E/PlexinD1 signalling (c). In the diagrams only two different cohorts of postmitotic CR cells are indicated in violet and blue. As indicated in the manuscript, with functional Sema3E/PlexinD1 signalling (b) the migratory properties of CR cells remained unaltered and they migrated following the described tangential routes (red arrow in a) towards dorsal cortex (b). In contrast, in the absence of Sema3E/PlexinD1 (c), although a whole population of CR cells migrated along preplate, they reached more dorsomedial regions. CP, cortical plate; GP, globus pallidus; LGE, lateral ganglionic eminences; MGE, medial ganglionic eminences; NCx, dorsal neocortex; PSB, pallial–subpallial boundary. Fig. 1.