Figure 3: Decreased energy expenditure in Wps/Wps mice.
From: The stem cell factor/Kit signalling pathway regulates mitochondrial function and energy expenditure
(a) Food intake of 8-week- and 10-month-old male mice (n=6). (b) Body-weight loss of 6-month-old male mice after 24 and 48 h of food deprivation (n=7). (c) RER, (d) ANCOVA analysis of body weight-adjusted heat production and (e) locomotor activity determined by metabolic cage study (n=17–18). (f) Rectal temperature of 6-month-old male mice after cold (4 °C) inducement (n=6–9). (g) Rectal temperature of 6-month-old male mice after 12 h fasting and 2 h refeeding (n=10–11). (h) Representative histology of BAT in wild-type and Wps/Wps mice. Scale bar, 50 μm. (i,j) Ucp1 gene expression of (i) cold- and (j) fasting-treated mice (n=4). (k) UCP1 protein expression in BAT from ad libitum fed mice housed at room temperature. Data are shown as mean±s.e.m. *P<0.05; **P<0.01 by two-tailed Student’s t-test.
