Table 2 Association results from the exome sequencing, targeted sequencing, replication and combined analyses by using logistic regression (additive model).
From: Sequencing-based approach identified three new susceptibility loci for psoriasis
Chr | Gene of interest | Variant ID | Stage* | Allele | MAF | P -value | OR (95% CI) | Combined | ||
|---|---|---|---|---|---|---|---|---|---|---|
Cases | Controls | P -value | OR (95% CI) | |||||||
12p13.3 | Multiple genes | rs758739 | i | G/C | 0.2662 | 0.2957 | 2.08 × 10−1 | 0.86 (0.72–1.04) | 4.08 × 10−8 | 0.91 (0.89–0.97) |
ii | G/C | 0.2681 | 0.2822 | 1.72 × 10−3 | 0.93 (0.89–0.97) | |||||
iii | G/C | 0.2642 | 0.2911 | 4.51 × 10−6 | 0.87 (0.83–0.93) | |||||
12p13.3 | Multiple genes | rs2243750 | i | C/T | 0.3026 | 0.3229 | 2.48 × 10−1 | 0.91 (0.76–1.05) | 4.38 × 10−8 | 0.91 (0.89–0.97) |
ii | C/T | 0.3265 | 0.3436 | 4.70 × 10−4 | 0.93 (0.89–0.97) | |||||
iii | C/T | 0.3056 | 0.3308 | 3.49 × 10−5 | 0.89 (0.84–0.94) | |||||
17q12 | IKZF3 | rs10852936 | i | T/C | 0.2795 | 0.2563 | 2.42 × 10−1 | 1.13 (0.88–1.25) | 1.96 × 10−8 | 1.10 (1.05–1.15) |
ii | T/C | 0.2972 | 0.2778 | 2.31 × 10−5 | 1.10 (1.05–1.15) | |||||
iii | T/C | 0.2939 | 0.2722 | 2.26 × 10−4 | 1.11 (1.05–1.18) | |||||
17q12 | IKZF3 | rs12936231 | i | G/C | 0.3019 | 0.2537 | 4.07 × 10−1 | 1.27 (1.11–1.96) | 5.02 × 10−8 | 1.10 (1.04–1.17) |
ii | G/C | 0.3015 | 0.2837 | 9.24 × 10−5 | 1.09 (1.04–1.14) | |||||
iii | G/C | 0.2928 | 0.2726 | 6.87 × 10−4 | 1.11 (1.04–1.17) | |||||
20q13.2 | RNF114 | rs4647954 | i | C/T | 0.4234 | 0.4021 | 2.49 × 10−1 | 1.09 (0.94–1.27) | 2.41 × 10−7 | 1.09 (1.05–1.14) |
ii | C/T | 0.4316 | 0.4105 | 2.27 × 10−5 | 1.09 (1.05–1.14) | |||||
iii | C/T | 0.4267 | 0.4086 | 6.04 × 10−3 | 1.08 (1.02–1.14) | |||||
3p21.31 | CDCP1 | rs1863837 | i | C/T | 0.2412 | 0.2494 | 6.82 × 10−1 | 0.96 (0.74–1.09) | 3.91 × 10−7 | 0.90 (0.86–0.95) |
ii | C/T | 0.2240 | 0.2414 | 8.87 × 10−5 | 0.91 (0.86–0.95) | |||||
iii | C/T | 0.2144 | 0.2356 | 2.06 × 10−3 | 0.89 (0.82–0.96) | |||||
17q25 | TRIM47 | rs3744017 | i | A/G | 0.1837 | 0.1490 | 1.34 × 10−2 | 1.26 (1.05–1.56) | 5.83 × 10−7 | 1.12 (1.05–1.17) |
ii | A/G | 0.1595 | 0.1462 | 2.70 × 10−4 | 1.11 (1.05–1.17) | |||||
iii | A/G | 0.1656 | 0.1522 | 5.70 × 10−3 | 1.11 (1.03–1.19) | |||||
