Figure 3: Schematic scale diagram of PAF1c and RNA Pol II.
From: Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour
PAF1c consists of six subunits: PAF1, LEO1, CDC73, CTR9, RFT1 and WDR61. CTR9 and CDC73 are cancer predisposition genes, mutations in which cause Wilms tumour and hyperparathyroidism-jaw tumour syndrome, respectively. RNA Pol II, RNA polymerase II.
