Figure 3: Multiple domains of CagA are responsible for Snail protein stabilization. | Nature Communications

Figure 3: Multiple domains of CagA are responsible for Snail protein stabilization.

From: Helicobacter pylori CagA promotes Snail-mediated epithelial–mesenchymal transition by reducing GSK-3 activity

Figure 3

(a) Schematic diagram of Flag-tagged CagA expression vectors. Arrows indicate EPIYA phosphorylation on AF202923; structural domains of CagA with corresponding amino acid sequence are denoted by rectangular boxes29. (b) The wt or mutant CagA expression vectors were co-transfected with a minimum amount of Snail (50 ng) and GFP (200 ng) expression vectors in 293 cells for a 48 h period and the whole-cell lysates were subjected to immunoblot analysis. CagA-PR denotes tyrosine PR mutant on EPIYA motifs. *specific bands.

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