Figure 5: Proposed mechanism for Nox2/Src-dependent impaired autophagy in DMD pathology.

(a) Autophagic machinery functions properly in WT condition through autophagosome and lysosome fusion, maintaining cellular homeostasis. (b) Upregulation of Nox2/Src activity prevents autophagolysosome formation, impairing autophagy and leading to cellular degeneration in DMD.