Figure 4: Inhibition of CaV1.2B15 current by compound 8 and nimodipine (Nimo).
From: Modest CaV1.342-selective inhibition by compound 8 is β-subunit dependent
(a) Representative traces of CaV1.2B15 currents, format as in Fig. 2a. (b) Averaged diary plot of effects of either control, 5 μM 8, 50 μM 8 or 5 μM Nimo on CaV1.2B15 peak currents, format as in Fig. 2b. (c) Population data of the % peak current inhibition at the 25th sweep normalized against the first sweep conferred by either 5 μM 8, 50 μM 8 or 5 μM Nimo as compared with the control. ***P<0.001. (Student’s unpaired t-test) Alternatively, P<0.001 among all the treatment groups (one-way analysis of variance and Bonferroni’s test). The number of cells analysed is indicated in b. The data for each condition were collected from two to three transfections.
