Figure 5: Inhibition of CaV1.342_UC current by compound 8 and nimodipine (Nimo).
From: Modest CaV1.342-selective inhibition by compound 8 is β-subunit dependent
(a) Representative traces of uncorrected CaV1.242_UC currents, format as in Fig. 2a. The current was recorded by single square pulse from holding of −70 to 10 mV for over 100 ms with sweep interval of 20 s. (b) Averaged diary plot of effects of either control, 5 μM 8, 50 μM 8 or 5 μM Nimo on CaV1.342_UC peak currents, format as in Fig. 2b. (c) Population data of the % peak current inhibition at the 28th sweep normalized against the first sweep conferred by either 5 μM 8, 50 μM 8 or 5 μM Nimo as compared with the control. *P<0.05, ***P<0.001 (Student’s unpaired t-test). Alternatively, P<0.001 among all the treatment groups (one-way analysis of variance and Bonferroni’s test). The number of cells analysed is indicated in b. The data for each condition were collected from two to three transfections.
