Figure 9: Schematic diagram showing LKB1–SIK pathway in the control of hepatic gluconeogenesis.
From: The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
Activity status of SIKs influences phosphorylation of transcription co-activators such as HDACs and CRTCs their nuclear-cytoplasm shuttling and gluconeogenic gene expressions in the liver.
