Figure 10: Schematic diagram of HGK-mediated reciprocal regulation between T cells and adipocytes. | Nature Communications

Figure 10: Schematic diagram of HGK-mediated reciprocal regulation between T cells and adipocytes.

From: HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance

Figure 10

HGK deficiency leads to constitutive TRAF2 overexpression and IL-6 overproduction in T cells. The circulating IL-6-producing T cells infiltrate to adipose tissue and enhance the production of leptin, which in turn cooperates with IL-6 to induce Th17 differentiation. The induction of adipose tissue Th17 cells leads to insulin resistance.

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