Figure 3: MdfA binds both groups of dicationic drugs (LDCs and SDCs).
From: Export of a single drug molecule in two transport cycles by a multidrug efflux pump
[3H]-TPP binding by wild-type MdfA and its inhibition by addition of increasing concentrations (25 or 125 μM) of dicationic drugs. Error bars indicate s.d. of triplicate measurements (*P<10−2; **P≤10−4 compared with the no drug sample, one tailed t-test). The experiments were repeated at least three times and the results shown are representative.
