Figure 4: Disruption of the YAP barrier for phenotypic transition significantly accelerates ADC to SCC transdifferentiation. | Nature Communications

Figure 4: Disruption of the YAP barrier for phenotypic transition significantly accelerates ADC to SCC transdifferentiation.

From: YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

Figure 4

(a) Scheme of Lentivirus-mediated Yap shRNA expression in KL mouse model. (b) YAP immunohistochemical staining in tumours from KL mice delivered with Lenti-U6-Cre or Lenti-shYap-Cre. Scale bar, 150 μm. (c) Representative images with haematoxylin and eosin and p63 immunohistochemical staining in ADC and SCC from KL mice delivered with Lenti-U6-Cre or Lenti-shYap-Cre. Scale bar, 150 μm. (d) Quantification of SCC incidence of KL mice delivered with Lenti-U6-Cre (n=7) or Lenti-shYap-Cre (n=6). (e,f) Quantification of tumour number (e) and tumour ratio (f) for ADC and SCC from KL mice delivered with Lenti-U6-Cre (n=7) or Lenti-shYap-Cre (n=6). Data are shown as mean±s.e.m. t-test, *P<0.05.

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