Figure 7: DNp63 rescues the inhibitory effect of YAP on SCC transdifferentiation. | Nature Communications

Figure 7: DNp63 rescues the inhibitory effect of YAP on SCC transdifferentiation.

From: YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression

Figure 7

(a) Scheme of ER-inducible DNp63 expression strategy in YKL-WT-32# mice. (b) Representative photos for haematoxylin and eosin and p63 immunohistochemical staining in YKL mice treated with TAM or sunflower oil after Lenti-DNp63 ER-Cre infection. Scale bar, 150 μm. (c) Quantification of SCC incidence of YKL-WT-32# mice treated with TAM (n=4) or sunflower oil (n=4) after Lenti-DNp63 ER-Cre infection. (d,e) Quantification of tumour number (d) and tumour ratio (e) for ADC and SCC from YKL-WT-32# mice treated with TAM (n=4) or sunflower oil (n=4) after Lenti-DNp63 ER-Cre infection. Data are shown as mean±s.e.m. t-test, *P<0.05.

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