Figure 3: Differential adaptive and innate immune responses to neonatal infection.
From: Identification of a human neonatal immune-metabolic network associated with bacterial infection
(a) Fold change in expression of adaptive immune response genes following neonatal infection. (b) Fold change in expression of innate immune response genes following neonatal infection. (c) Fold change in expression of genes associated with myeloid-derived suppressor cells following neonatal infection. Significance is indicated by adjusted P-values for fold change of each probe (using eBayes with Benjamini-Hochberg correction). (d) Neutrophil cell counts from control and infected patients. Neutrophil cell counts were examined in control (n=12) and infected (n=28) patients and are expressed as numbers × 106 cells per ml of blood with the plot presenting median values±median absolute deviation. Significance testing between conditions was performed using a one-way analysis of variance test, * indicates significance at P<0.0005. (e,f) Cell type enrichment analysis. Volcano plots of expression profiles associated with particular blood cell types and classes. Gene lists used to perform this analysis are detailed in Supplementary Data set 2. Log2 fold change is on the x axis and –log2 adjusted P value on the y axis (using eBayes with Benjamini–Hochberg correction). (e) Expression profiles for lymphoid and myeloid cells. (f) Expression profiles for B, T, NK cells, neutrophils, monocytes and dendritic cells. Significantly differentially expressed probes (with adj.P≤0.01) are shown in red.
