Figure 1: Genetic association with candidaemia.

(a) Manhattan plot showing the genome-wide P values of association with candidaemia. The y axis represents the −log₁₀ P values of 118,989 SNPs and their chromosomal positions are shown on the x axis. The horizontal red line shows the genome-wide significant threshold of P<5 × 10⁻⁸. The P-values were obtained by logistic regression test after adjusting for the first four components from the multidimensional scaling analysis. Regional association plots at (b) 1p13.1, (c) 1q21.3 and (d) 6q25.3. The P values of genotyped SNPs are plotted as –log₁₀ values against their physical chromosomal positions (hg19). Estimated recombination rates from the 1000 Genomes European population show the local LD structure. Inset, the colours of the SNPs indicate LD with the top-associated SNPs according to a scale from r²=0 to r²=1 based on pairwise r² values from the 1000 Genomes European population. Lower panel, gene annotations from the University of California Santa Cruz genome browser (hg19).