Figure 6: Rescue effect of MK6-83.
From: A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV
(a,b) Effects of 10 μM DMSO or MK6-83 on BODIPY FL C5-LacCer trafficking in human patient fibroblasts. Shown are the representative cells in a. Quantification is shown in b: mean values±s.e.m. of at least 20 cells from three independent experiments; *P<0.05. Statistical significance was determined via one-way analysis of variance followed by Tukey’s post test. (c) Effects of 10 μM DMSO or MK6-83 on lysosomal zinc accumulation in human patient fibroblasts. (d) Quantification of experiments as shown in c.
