Table 1 Three-stage study design of ovarian cancer GWAS in Chinese women.

From: Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women

 

No. of SNPs

Genotyping method

Source of population

Controls

Cases

    

N

Age (mean±s.d.)

N

Age (mean±s.d.)

Stage I

900,015

Illumina HumanOmniZhongHua-8 BeadChip

Northern*

425

55.40±9.49

429

54.80±10.37

   

Southeasthern

747

52.86±10.81

615

54.10±10.43

   

Stage I total

1,172

52.86±10.81

1,044

54.39±10.40

Stage II

51

Sequenom MassArray iPlex

Southeasthern

899

54.75±10.97

552

53.33±10.18

   

Southern§

900

51.87±13.38

408

50.70±12.49

   

Stage II total

1,799

53.31±12.32

960

52.21±11.29

Stage III

51

Sequenom MassArray iPlex /Taqman

Northern||

1,004

52.50±11.44

492

53.69±11.79

  1. GWAS, genome-wide association study; SNP, single-nucleotide polymorphism.
  2. *Northern Han population in stage I was recruited from Tianjin and Beijing in northern China.
  3. Southeastern Han population in stage I and stage II was recruited from Shanghai and Nanjing in southeastern China.
  4. Forty-one newly identified SNPs and ten previously reported SNPs.
  5. §Southern Han population in stage II was recruited from Guangzhou in southern china.
  6. ||Northern Han in stage III was recruited from Tianjin and Shandong province in northern China.