Table 2 Summary of GWAS scan and replication studies for the four SNPs.

SNP	Locus	Allele ^*	Proposed candidate	Stage	Population	MAF (cases/controls)	OR (95% CI)	P -value ^†	P _meta ^‡	P _meta ^§
rs1413299	9q22.33	A/C	COL15A1/TGFBR1	Ia	N	0.48/0.38	1.53 (1.25–1.86)	2.47 × 10⁻⁵	7.20 × 10⁻⁶	1.88 × 10⁻⁸
				Ib	SE	0.46/0.42	1.21 (1.04–1.41)	1.60 × 10⁻²
				IIa	S	0.44/0.41	1.14 (0.97–1.36)	1.21 × 10⁻¹	4.00 × 10⁻³
				IIb	SE	0.46/0.42	1.22 (1.04–1.41)	1.16 × 10⁻²
				III	N	0.42/0.38	1.20 (1.03–1.41)	1.89 × 10⁻²
rs1192691	10p11.21	C/A	NAMPTL/ANKRD30A	Ia	N	0.43/0.46	0.89 (0.73–1.07)	2.20 × 10⁻¹	6.02 × 10⁻⁵	2.62 × 10⁻⁸
				Ib	SE	0.38/0.46	0.71 (0.60–0.83)	2.48 × 10⁻⁵
				IIa	S	0.38/0.41	0.89 (0.75–1.06)	1.82 × 10⁻¹	3.00 × 10⁻³
				IIb	SE	0.38/0.44	0.80 (0.68–0.93)	4.50 × 10⁻³
				III	N	0.41/0.46	0.81 (0.70–0.95)	8.74 × 10⁻³
rs11175194	12q14.2	G/A	SRGAP1	Ia	N	0.32/0.40	0.72 (0.59–0.88)	1.32 × 10⁻³	9.75 × 10⁻⁵	1.14 × 10⁻⁷
				Ib	SE	0.34/0.38	0.82 (0.70–0.96)	1.61 × 10⁻²
				IIa	S	0.38/0.43	0.83 (0.70–0.98)	3.06 × 10⁻²	3.58 × 10⁻³
				IIb	SE	0.36/0.40	0.86 (0.73–1.00)	5.01 × 10⁻²
				III	N	0.37/0.41	0.84 (0.72–0.98)	2.84 × 10⁻²
rs633862	9q34.2	A/G	ABO/SURF6	Ia	N	0.40/0.48	0.72 (0.59–0.87)	8.05 × 10⁻⁴	2.99 × 10⁻⁵	8.57 × 10⁻⁷
				Ib	SE	0.41/0.45	0.80 (0.68–0.95)	8.35 × 10⁻³
				IIa	S	0.50/0.55	0.85 (0.72–1.01)	5.75 × 10⁻²	2.38 × 10⁻²
				IIb	SE	0.41/0.43	0.90 (0.77–1.05)	1.92 × 10⁻¹
				III	N	0.42/0.46	0.84 (0.72–0.98)	2.89 × 10⁻²

CI, confidence interval; GWAS, genome-wide association study; MAF, minor allele frequency; N, Northern population; OR, odds ratio; S, Southern population; SE, Southeastern population; SNP, single-nucleotide polymorphism.
^*Major allele/minor allele.
^†P-value, OR and 95% CI were assessed under an additive model using logistic regression adjusted for age and the first three principal components of population stratification in stage I, and adjusted for age in stages II and III.
^‡Meta-analysis P-value of each stage.
^§Meta-analysis P-value for all three stages.

Search