Table 3 Ovarian cancer risk associated with the four identified SNPs in stratified analysis by histological subtype.
SNP | Chr. | Proposed candidate gene | Pathology type | Case/control | MAF (cases/controls) * | OR (95% CI) † | P -value † | Q-P ‡ |
|---|---|---|---|---|---|---|---|---|
rs1413299 | 9q22.33 | COL15A1/TGFBR1 | Serous | 1,320/3,964 | 0.455/0.401 | 1.246 (1.139–1.377) | 2.13E–06 | 1.03E–01 |
Mucinous | 167/3,964 | 0.437/0.401 | 1.127 (0.905–1.405) | 2.97E–01 | ||||
Endometriod | 277/3,964 | 0.419/0.401 | 0.980 (0.803–1.209) | 8.76E–01 | ||||
Others | 720/3,964 | 0.457/0.401 | 1.297 (1.150–1.448) | 9.69E–06 | ||||
rs1192691 | 10p11.21 | NAMPTL/ANKRD30A | Serous | 1,310/3,898 | 0.395/0.445 | 0.795 (0.719–0.869) | 1.13E–06 | 8.86E–01 |
Mucinous | 165/3,898 | 0.412/0.445 | 0.869 (0.691–1.094) | 2.19E–01 | ||||
Endometriod | 273/3,898 | 0.396/0.445 | 0.827 (0.677–1.010) | 6.90E–02 | ||||
Others | 719/3,898 | 0.399/0.445 | 0.827 (0.733–0.923) | 1.16E–03 | ||||
rs11175194 | 12q14.2 | SRGAP1 | Serous | 1,321/3,973 | 0.351/0.403 | 0.827 (0.748–0.905) | 6.22E–05 | 5.91E–01 |
Mucinous | 167/3,973 | 0.359/0.403 | 0.827 (0.657–1.041) | 1.10E–01 | ||||
Endometriod | 277/3,973 | 0.325/0.403 | 0.726 (0.589–0.896) | 3.36E–03 | ||||
Others | 718/3,973 | 0.368/0.403 | 0.861 (0.763–0.970) | 1.40E–02 | ||||
rs633862 | 9q34.2 | ABO/SURF6 | Serous | 1,312/3,947 | 0.415/0.450 | 0.861 (0.787–0.951) | 1.95E–03 | 4.56E–01 |
Mucinous | 166/3,947 | 0.452/0.450 | 0.869 (0.691–1.094) | 2.24E–01 | ||||
Endometriod | 274/3,947 | 0.401/0.450 | 0.726 (0.589–0.896) | 2.50E–03 | ||||
Others | 720/3,947 | 0.421/0.450 | 0.803 (0.712–0.896) | 1.93E–04 |
