Figure 8: The role of KLF4 and BMI1 in Twist1-induced in vivo metastatic activity.
From: Twist1 induces endothelial differentiation of tumour cells through the Jagged1-KLF4 axis
(a,b) Gross and histology pictures of lung metastatic nodules generated by injecting various stable clones. (c) Measurement of the number of metastatic lung tumour nodules (bar graph). The OECM1-Twist1 clone was selected as the control group. Luc-si: siRNA against the luciferase gene as a negative control. Data shown in panel c are mean±s.d. of five mice injected with various stable clones in each group. Asterisk (*) indicates statistical significance (P<0.05 by Student’s t-test) between experimental and OECM1-Twist1 control (cont.) clones.
