Figure 3: Direct amination of aromatic C–H bonds.
From: Silver-catalysed direct amination of unactivated C–H bonds of functionalized molecules
aUnless otherwise noted, the reaction conditions were as follows: sulphonamide (0.25 mmol), AgOAc (1.0 equiv), PhI(OTFA)2 (2.0 equiv), ligand (20 mol%), K2CO3 (2.0 equiv), PhCl/dichloroethane (DCE) (1.5 ml/1.5 ml), 120 °C, 12 h. The isolated yield was shown in the parentheses. bSulphonamide (0.25 mmol), AgOAc (1.0 equiv), PhI(OTFA)2 (2.0 equiv), ligand (20 mol%), K2CO3 (2.0 equiv), PhCl/DCE(1.0 ml/1.0 ml), 120 °C, 2 h; then another PhI(OTFA)2 (2.0 equiv) was added and the reaction was continued for 2 h. cThe ratio was determined by crude 1H NMR of the crude reaction mixture.
