Figure 4: Manhattan plot of the MHC region from HLA imputation.
From: Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles
This figure shows the association results of CIAG to imputed HLA classical alleles, amino acids and SNPs for 161 cases and 4,300 controls. (a) The top signal is from a single amino acid in HLA-DQB1 (126Q) (P=4.7 × 10−14, OR=0.19, logistic regression). All variants with an R2>0.1 with HLA-DQB1 126Q are coloured green. (b) After conditioning on HLA-DQB1 126Q as demonstrated by the green arrow, the top signal is a single amino acid in HLA-B (158T) (Pcond=1.54 × 10−8, OR=3.11, logistic regression). All variants with an R2>0.1 with HLA-B 158T are coloured purple. (c) After conditioning on HLA-DQB1 126 Q and HLA-B 158T (purple and green arrows), no genome-wide significant loci remain.
