Figure 1: Basal and luminal cells exhibit different polarization patterns. | Nature Communications

Figure 1: Basal and luminal cells exhibit different polarization patterns.

From: Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages

Figure 1

(a) Immunostaining of Par3 and CK8 shows that luminal cells are polarized with Par3-dependent tight junctions. (b) Immunostaining of Par3 and ZO-1 shows that Par3 is colocalized with ZO-1 at tight junctions of luminal cells. Yellow arrowheads indicate the tight junctions between two adjacent luminal cells. (c) Immunostaining of Par3 and p63 shows that Par3 is expressed at the apical end in basal cells. Yellow arrowheads point to a basal cell with polarized Par3 location. (d) Immunostaining of aPKC and p63 shows that aPKC is also expressed at the apical end in basal cells. Yellow arrowheads point to a basal cell with polarized aPKC location. (e) Immunostaining of aPKC and E-cadherin shows that prostate luminal cells are connected by tight junctions and adherens junctions, respectively. All sections are originated from anterior lobes of prostate (AP) tissues and counterstained by 4',6-diamidino-2-phenylindole (DAPI) (blue). Scale bars, 10 μm for each related row.

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