Figure 6: Pten loss disrupts the polarity of luminal cells. | Nature Communications

Figure 6: Pten loss disrupts the polarity of luminal cells.

From: Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages

Figure 6

(a) Polarity analysis of luminal cells stained for Par3 and E-cadherin in Wt and Pten-null prostates (6 weeks). Note that Pten loss disrupts the polarity of luminal epithelium. (b) aPKC immunostaining of dividing luminal cells in Wt and Pten-null prostate sections. (c) Spindle orientation analysis of dividing luminal cells in Wt and Pten-mutant prostate by staining for CK5 and P-H3. (d) Quantification of spindle orientations of luminal cells from Wt and Pten-null prostate (6, 9 weeks). See Supplementary Table S8 for further data. Dashed lines in b, c denote the positions of the basement membrane (bold) and the cell boundary of dividing luminal cells (light). Scale bars, 10 μm for related panels.

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