Table 2 Validated somatic mutations.

Gene symbol	Ref seq_no.	Amino-acid change	Position (hg19)	Base change	Mutation type	SIFT prediction	VAF at MDS/MF (%)	VAF at AML (%)
Subject 20
AGAP4	NM_133446	p.Arg484Cys	g.chr10:46321905	C->T	Missense	Damaging	13.2	11.5
CDC25C	NM_001790	p.Asp234Gly	g.chr5:137627720	A->G	Missense	Damaging	31.7	45.8
CHEK2	NM_007194	p.Arg406His	g.chr22:29091740	G->A	Missense	Tolerated	14.6	11.1
COL9A1	NM_001851	p.Gly878Val	g.chr6:70926733	G->T	Missense	Damaging	9.6	26.4
DTX2	NM_001102594	p.Pro74Arg	g.chr7:76110047	C->G	Missense	Damaging	18.3	11.2
FAM22G	NM_001170741	p.Ser508Thr	g.chr9:99700727	T->A	Missense	Tolerated	10.2	27.6
GATA2	NM_001145661	p.Leu321His	g.chr3:128202758	T->A	Missense	Damaging	0.0	28.1
LPP	NM_001167671	p.Val538Met	g.chr3:188590453	G->A	Missense	Damaging	9.7	28.8
RP1L1	NM_178857	p.Ser215fs	g.chr8:10480295	insC	Frameshift	Damaging	14.2	12.7
SIGLEC9	NM_014441	p.Ser437Gly	g.chr19:51633253	A->G	Missense	Tolerated	27.4	42.5
Subject 21
ANXA8L1	NM_001098845	p.Val281Ala	g.chr10:48268018	T->C	Missense	Damaging	30.8	36.8
CDC25C	NM_001790	p.Asp234Gly	g.chr5:137627720	A->G	Missense	Damaging	31.1	39.1
DENND5A	NM_001243254	p.Arg320Ser	g.chr11:9215218	A->C	Missense	Damaging	29.5	37.3
FER	NM_005246	p.Tyr634Cys	g.chr5:108382876	A->G	Missense	Damaging	1.4	30.4
FNDC1	NM_032532	p.Arg189Cys	g.chr6:159636081	C->T	Missense	Damaging	29.3	35.9
OR8U1	NM_001005204	p.Asn175Ile	g.chr11:56143623	A->T	Missense	Damaging	30.0	34.1
PIDD	NM_145886	p.Arg342Cys	g.chr11:802347	C->T	Missense	Damaging	3.3	28.3
ZNF614	NM_025040	p.Glu202Gly	g.chr19:52520246	A->G	Missense	Damaging	28.7	33.7

AML, acute myeloid leukemia; MDS, myelodysplastic syndrome; MF, myelofibrosis; SIFT, sorting intolerant from tolerant; VAF, variant allele fraction.

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