Figure 10: FGF/MAPK inputs sequentially govern PCP versus anterior CNS formation. | Nature Communications

Figure 10: FGF/MAPK inputs sequentially govern PCP versus anterior CNS formation.

From: Fibroblast growth factor signalling controls nervous system patterning and pigment cell formation in Ciona intestinalis

Figure 10

Summary of pigmented cell development within CNS; embryonic stage drawings are indicated below the time line (hpf, hours post fertilization). Black bars connect sister cells. At 6 hpf embryo, the bilateral a9.50s are marked in blue; a9.49 cell pair (in pink) are in close proximity to two sources of FGF signalling molecules, Ci-FGF8/17/18 (light green) and Ci-FGF9/16/20 (dark green) in the underneath row, respectively. Cell lineage scheme indicate one side of the embryo and the colour code of cells remains the same used in the upper drawings. Red arrows indicate FGF/MAPK signalling mediated inductions. a8.25-derived cells with specific gene expression patterns: boxes represent a9.50- and a9.49-derived cells with the same colour code used in the upper drawings. FGFRDN: dominant-negative form of FGF receptor; Ets:Vp16: constitutive active form of Ets1/2.

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