Figure 5: Iron acquisition/utilization pathways directly regulated by Fur and regulatory network motif. | Nature Communications

Figure 5: Iron acquisition/utilization pathways directly regulated by Fur and regulatory network motif.

From: Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli

Figure 5

(a) The iron acquisition (enterobactin biosynthesis and iron/enterobatin transport), iron utilization (iron storage and iron/FeS cofactors) and FeS assembly pathways are represented. The genes regulated by HR and HA are depicted by red and blue characters, respectively. The genes regulated by RyhB-mediated mRNA degradation are depicted by green characters with black boxes. 2,3-DHBA, 2,3-dihydroxybenzoic acid; IM, inner membrane; OM, outer membrane. (b) Schematic diagram for the Fur regulatory motif reconstruction for iron metabolism. Shaded grey boxes indicate motif loops utilized by E. coli K-12 MG1655 for iron metabolism (negative/negative feedback loop motifs achieved by HR/HA modes of regulation).

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