Figure 8: Bax is essential for SMBA suppression of lung cancer in xenograft models.
(a) Expression levels of Bax and Bak in A549 cells that persistently express Bax siRNA or control (Ctrl) siRNA were analysed by western blot (full blots can be found in Supplementary Fig. 10). (b,c) Mice with xenografts derived from A549 expressing Bax siRNA, or Ctrl siRNA were treated with SMBA1 (40 mg kg−1) or vehicle for 14 days. Tumour volume and active caspase 3 in tumour tissues were analysed. Scale bar, 10 μm. The error bars indicate ±s.d. Statistical significance was analysed with two-sided unpaired Student’s t-test.
