Figure 6: Logically switching a G-quadruplex DNAzyme.
From: Interlocked DNA nanostructures controlled by a reversible logic circuit
(a) Working principle of a DNAzyme nanoswitch built on the difference in robustness between the bimolecular i-motif (cyan) and the G-quadruplex (purple) structures on the head-motifs of the interlocked architecture. (b) Normalized absorbance of the DNAzyme switch on different inputs, consistent with the output of logic circuit. (c) Control experiment for the switch. The control structure is a [3]pseudocatenane with only G-quadruplex structure (that is, no i-motif) on the heads. (d) Working cycles of the nanoswitch between the inactive and active states in response to external stimuli.
