Figure 1: Temporally structured maximum clade credibility phylogenetic tree of the NA gene of seasonal H1N1 viruses, showing the timeline of amino acid substitutions. | Nature Communications

Figure 1: Temporally structured maximum clade credibility phylogenetic tree of the NA gene of seasonal H1N1 viruses, showing the timeline of amino acid substitutions.

From: Epistatic interactions between neuraminidase mutations facilitated the emergence of the oseltamivir-resistant H1N1 influenza viruses

Figure 1

Ancestral state reconstruction of tested amino acids is annotated on the tree backbone to indicate when specific mutations were fixed in the population. The trunk colour change indicates a >95% posterior probability of amino acid fixation. Purple bars on tree nodes indicate the Bayesian credible intervals of ancestral divergence time estimates (>50% posterior probability). Isolates with H275Y mutation before H275Y fixation into the population are indicated with red branches.

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