Figure 2: OD plasticity in wild type and mice with specific Mecp2 deletion in different neuronal types. | Nature Communications

Figure 2: OD plasticity in wild type and mice with specific Mecp2 deletion in different neuronal types.

From: Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity

Figure 2

(a) Top: 7-Scale histograms of OD of V1 neurons based on the measured OD index (ODI) from normally reared (black) and 4-d MD (blue) young WT mice, with calculated CBI. ‘Contra’ and ‘Ipsi’ refer to preferential responses to inputs from the contra- and ipsilateral eyes, respectively, and the cross represents the visual deprivation. Bottom: Cumulative percentage distribution of ODI shown in top. ODI ranges from +1 for neurons driven exclusively by the ipsilateral eye to −1 for those driven exclusively by the contralateral eye. (b) 7-Scale histograms and cumulative percentage distribution of ODIs for young PV-Mecp2−/y mice with (blue) and without (black) MD treatment. (c–f) Cumulative percentage distributions for ODIs with (blue) and without (black) MD treatment. Data collected from: (e) P30 PV-Cre and P30 flox-Mecp2, (f) P30 Sst-Mecp2−/y and (g) P30 Nex-Mecp2−/y. P-values were calculated by Kolmogorov–Smirnov test.

Back to article page