Figure 3: Intact V1 function and aberrant OD plasticity in adult PV-Mecp2−/y mice. | Nature Communications

Figure 3: Intact V1 function and aberrant OD plasticity in adult PV-Mecp2−/y mice.

From: Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity

Figure 3

(a) The mean RF size of V1 binocular cells recorded in adult WT (black) and PV-Mecp2−/y (green) mice (P=0.35, t-test). (b) Plot of V1 cells RF-centre azimuths relative to the M−L position from adult WT and PV-Mecp2−/y mice. (c) Cumulative percentage distribution of orientation selectivity indices (OSIs) from all V1 cells from adult WT and PV-Mecp2−/y mice. No significance was found between the data from the two genotypes (P=0.19, Kolmogorov–Smirnov test). (d) The dependence of spike rate on the spatial frequency of drifting gratings of all recorded V1 cells from adult WT and PV-Mecp2−/y mice. (e,f) Cumulative percentage distributions of ODIs for all recorded cells with (blue) and without (black) MD treatment from adult WT (e) and PV-Mecp2−/y (f) mice. P-values were calculated by the Kolmogorov–Smirnov test. Average data are presented as mean±s.e.m.

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