Figure 5: Intrinsic excitability of layer 4 PV and PCs in the four different genotypes. | Nature Communications

Figure 5: Intrinsic excitability of layer 4 PV and PCs in the four different genotypes.

From: Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity

Figure 5

(a) Example recording traces depicting action potential firing of PV cells in response to step depolarizing currents (duration 600 ms) in slices from P30 WT (black), PV-Cre (red), flox-Mecp2 (blue) and PV-Mecp2−/y (green) mice. (b) Plot of evoked spike rates versus current magnitudes (I/O curve) of PV cells from WT and other three genotypes. *0.01<P<0.05, t-test. (c,d) Same tests on PC cells recorded from same slices of the four different genotypes. (e,f) Same tests on PV cells recorded from cortical slices of P50 PV-Mecp2−/y (purple) mice. P-values were calculated by t-test when comparing with the data from P30 PV-Mecp2−/y (light green). Average data are presented as mean±s.e.m.

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