Table 2 Differential expression in the SpnD39IIIB variant strain relative to the other SpnD39III variants*.

From: A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

D39 ORF

Gene

Description

SpnIIIA

SpnIIIC

SpnIIID

SPD_0309

luxS

LuxS S-ribosylhomocysteine lyase

−4.9

−4.2

−3.8

SPD_0310

(unnamed)

Uncharacterized protein

−4.5

−4.1

−4.0

SPD_0311

dexB

Glucan 1,6-alpha-glucosidase

−3.4

−4.6

−4.5

SPD_0315

cps2A

LCP capsule anchoring protein

−4.0

−4.3

−4.2

SPD_0316

cps2B

Tyrosine-protein phosphatase

−3.1

−3.2

−3.1

SPD_0317

cps2C

Polysaccharide transport protein

−2.5

−2.7

−2.6

SPD_0318

cps2D

Tyrosine-protein kinase

−2.1

−2.6

−2.5

SPD_0321

cps2F

Glycosyl transferase

−2.3

−2.7

−2.6

SPD_0322

cps2G

Glycosyl transferase

−2.4

−2.8

−3.3

SPD_0323

csp2H

Polysaccharide polymerase

−2.2

−2.6

−2.9

SPD_0325

cps2J

Membrane protein

−2.9

−3.0

−3.9

SPD_0326

cps2K

UDP-glucose 6-dehydrogenase

−2.9

−2.7

−3.0

SPD_0327

cps2P

UDP-galactopyranose mutase

−2.6

−3.3

−3.9

SPD_0328

cps2L

Glucose-1-P thymidylyltransferase

−2.3

−3.2

−4.0

SPD_0330

rfbB

dTDP-glucose 4,6-dehydratase

−2.1

−3.3

−4.1

SPD_0331

rfbD

dTDP-4-dehydrorhamnose reductase

−2.1

−3.0

−3.7

SPD_0332

(unnamed)

Uncharacterized protein

−2.5

−3.4

−3.5

  1. *Log2 fold change in gene expression as assessed by RNA-seq. Data are deposited in the NCBI GEO database with accession code GSE55182.