Table 3 Differential expression in the SpnD39IIIA variant strain*.

From: A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

D39 ORF

Gene

Description

SpnIIIB

SpnIIIC

SpnIIID

SPD_0257

 

Uncharacterized protein

2.4

2.2

2.6

SPD_0286

 

Glutathione peroxidase

2.4

2.7

2.2

SPD_0460

dnaK

Chaperone protein DnaK

2.8

2.5

2.7

SPD_0473

blpY

Immunity protein BlpY

−5.0

−4.6

−3.3

SPD_0474

 

Uncharacterized protein

−5.6

−4.8

−3.1

SPD_0475

 

CAAX protease

−5.3

−4.5

−2.9

SPD_0675

 

Uncharacterized protein

−3.6

−2.9

−2.1

SPD_0708

 

Haloacid dehalogenase-like hydrolase

−2.0

−2.6

−2.5

SPD_1256

 

Peptidase, U32 family protein

−3.4

−3.0

−3.9

SPD_1307

Uncharacterized protein

−2.0

−2.2

−2.2

SPD_1415

 

Pyrimidine nucleotide sulfite reductase

2.3

2.7

3.6

SPD_1452

 

Uncharacterized protein

−2.4

−2.3

−2.4

SPD_1461

psaB

Manganese ABC transporter, ATP binding

2.8

2.9

2.6

SPD_1462

psaC

Manganese ABC transporter, permease

3.0

3.0

2.7

SPD_1463

psaA

Manganese, substrate-binding lipoprotein

2.6

2.9

2.7

SPD_1535

scrR

Sucrose operon repressor

−2.2

−2.1

−2.4

SPD_1992

 

PTS system, IIA component

−2.7

−2.6

−2.4

SPD_1993

fucU

L-fuculose transport protein

−2.2

−2.6

−2.2

SPD_1994

fucA

L-fuculose phosphate aldolase

−2.2

−2.5

−2.0

SPD_1995

fucK

L-fuculose kinase FucK

−2.4

−2.6

−2.4

sRNA_F26

 

RNA downstream livJ

2.4

2.2

2.3

sRNA_SN46

 

RNA upstream pcpA

2.4

3.5

2.5

  1. Data are deposited in the NCBI GEO database with accession code GSE55182.
  2. *Log2 fold change in gene expression as assessed by RNA-seq.
  3. A SpnD39IIIA site maps in a non-coding RNA preceding the gene.