Figure 8: GM-CSF production by CD8+ T cells is not altered in the context of MS. | Nature Communications

Figure 8: GM-CSF production by CD8+ T cells is not altered in the context of MS.

From: Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

Figure 8

(a–c) The frequency of cytokine-secreting CD8+ T cells determined by flow cytometry without prior in vitro culture. Shown are a representative GM-CSF and IFN-γ secretion profile of CD8+ T cells (a), cumulative frequencies of GM-CSF-secreting CD8+ T cells from untreated MS (n=27) versus OND patients (n=22; b) and cumulative frequencies of GM-CSF-secreting CD8+ T cells with a protective (G/G or A/G) or risk IL2RA genotype (A/A) at rs2104286 (protective n=37, rs2104286 n=52; c). Data are combined from >3 independent experiments. Each circle represents a single individual. Throughout all figures lines represent the median.

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