Figure 5: Alternative model parameterizations quantitatively fit the experimental data.
From: Dynamic scaling of morphogen gradients on growing domains
The predicted length of the exponential gradient, λ(t), at different domain lengths, L(t), (solid line) and the measured values (red dots)15. (a) A 100-fold higher diffusion coefficient can be compensated by a 100-fold higher Dpp-Tkv binding rate (kon). However, the predicted fraction of free ligand would then be much smaller than 1%. (b) A fivefold higher degradation rate (kdeg=2 × 10−5 s−1) can be compensated by a slightly higher diffusion coefficient (DDpp) and a slightly higher Dpp-Tkv binding rate (kon). All quantitative data, including the fraction of free ligand, would still be reproduced. The alternative parameterizations are listed in Supplementary Table 1.
