Table 1 Secretory proteins upregulated in CAFs compared with HOSE, NOFs and ovarian cancer epithelia.

From: Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential

Probe set

Gene

Accession

Fold change

P -value

223122_s_at

SFRP2: secreted frizzled-related protein 2

AF311912

10.29

0.000082

213764_s_at

MFAP5: mircofibrillar-associated protein 5

AW665892

10.54

0.001128

1555778_a_at

POSTN: periostin

AY140646

11.13

0.008831

203570_at

LOXL1: lysyl oxidase-like 1

NM_005576

11.76

0.000043

231993_at

ITGBL1: osteoblast-specific cysteine-rich protein

AK026784

11.89

0.005861

232523_at

MEGF10: multiple EGF-like-domains 10

AU144892

11.98

0.008406

212489_at

COL5A1: collagen, type V, alpha 1

AI983428

12.22

0.000010

209156_s_at

COL6A2: collagen, type VI, alpha 2

AY029208

12.43

0.000000

215446_s_at

LOX: lysyl oxidase

L16895

12.85

0.000013

205479_s_at

PLAU: plasminogen activator, urokinase

NM_002658

13.86

0.000033

206091_at

MATN3: matrilin 3

NM_002381

14.22

0.017423

221731_x_at

VCAN: versican

BF218922

14.85

0.000000

213905_x_at

BGN: biglycan

AA845258

15.21

0.000000

204320_at

COL11A1: collagen, type XI, alpha 1

NM_001854

16.61

0.000017

226930_at

FNDC1: fibronectin type III domain containing 1

AI345957

17.32

0.000003

210511_s_at

INHBA: inhibin, beta A

M13436

20.98

0.000006

218002_s_at

CXCL14: chemokine (C-X-C motif) ligand 14

NM_004887

24.38

0.000089

205713_s_at

COMP: cartilage oligomeric matrix protein

NM_000095

43.14

0.000054

206439_at

EPYC: epiphycan

NM_004950

48.64

0.000561

  1. CAF, cancer-associated fibroblast; FDR, false discovery rate; HOSE, human ovarian surface epithelia; NOF, normal ovarian fibroblast.
  2. By transcriptome analysis, 19 significantly upregulated secretory protein-coding genes were identified in microdissected CAF samples (P<0.05; t-test and Benjamini–Hochberg FDR multiple testing).