Figure 5: Aged A20IEC/myel-KO mice develop colorectal tumours.
From: A20 controls intestinal homeostasis through cell-specific activities
(a) Representative macroscopic images of colons from 40-week-old wild-type (WT) and A20IEC/myel-KO mice (Scale bars, 5 mm). (b) Representative endoscopic images of 40-week-old wild-type (WT) and tumour-bearing A20IEC/myel-KO mice. Arrows indicate adenomatous neoplasms. (c) AB-PAS staining on colon sections of aged A20IEC/myel-KO mice. Dashed lines indicate dysplastic crypt areas (Scale bars, 100 μm left, 50 μm right). (d,e) Immunostaining on colon sections of aged wild-type (WT) and A20IEC/myel-KO mice for β-catenin (d) and Sox-9 (e) (Scale bars, d: 150 μm, e: 50 μm). Dashed squares indicate dysplastic areas with high β-catenin and Sox-9 expression. (f) In situ hybridization for Olfm4 on colon sections from aged wild-type (WT) and A20IEC/myel-KO mice (Scale bars, upper 150 μm, lower 20 μm).
