Figure 7: A20 deficiency influences gut microbial composition.
From: A20 controls intestinal homeostasis through cell-specific activities
Microbiota analysis by 16S rDNA pyrosequencing of wild-type (WT), A20IEC-KO, A20myel-KO and A20IEC/myel-KO mice: (a) Distribution of observed microbiota richness. (b) Average weighted UniFrac distance (distance between communities on the basis of abundance and bacterial phylogenetics) within- and between-mouse genotypes. Anosim test with star phylogeny: *P<0.05, **P<0.001. Anosim with bacterial phylogenetic tree:+P<0.05. (c) Phylum-level comparisons of compiled samples. (d) Phylum-level abundance variation after controlling for cage-effects. Wilcoxon (BH correction). *P<0.05. W= WT, E=A20IEC-KO, M=A20myel-KO and D=A20IEC/myel-KO.
