Table 1 Pol II insertions (I–VII) and their interactions with GTFs and Mediator.
From: The X-ray crystal structure of the euryarchaeal RNA polymerase in an open-clamp configuration
Group | Insertions | Domains having these insertions | Binding factors | References |
|---|---|---|---|---|
I | i3, i4, i8, i26 and i27 | Foot and cleft (Rpb1), N- and C-terminal tails (Rpb6) | ||
II | i5, i6 and i7 | Jaw (Rpb1) | TFIIH | |
III | i2 and i25 | Clamp head (Rpb1) and jaw (Rpb5) | ||
IV | i10, i15, i16 and i17 | External 1 (Rpb2) | ||
V | i11, i12, i13 and i14 | Protrusion, lobe and fork (Rpb2) | TFIIF | |
VI | i18, i19, i20, i21, i22, i28, i29 and i30 | Domain 2 and tail (Rpb3), N- and C-terminal tails (Rpb11) and zinc ribbon (Rpb12) | Mediator | |
VII | i1, i9, i23 and i24 | Clamp core and CTD (Rpb1), tip-associated (Rpb4) | Mediator |
