Figure 6: Rescue of Drosha under anti-VEGF therapy results in decreased tumour progression in vivo.
From: Hypoxia-mediated downregulation of miRNA biogenesis promotes tumour progression
(a,b) Effect of rescue of Drosha after anti-vascular endothelial growth factor (VEGF) therapy in A2780 model. Aggregate tumour weight is shown (a) and number of distant metastatic nodules (b) in mice treated with bevacizumab and mice treated with siRNAs against ETS+ELK1. Also shown are representative pictures of tumour burden (a, bottom) in all treatment groups (n=5 per group). (c) Distribution of metastatic nodules in individual mice groups treated with siDicer, siDrosha and siDicer+siDrosha. Hypoxia marker CA9 (d) and Dicer and Drosha (e) mRNA expression levels in the tumour samples from the mouse model. All images shown are representative and data are presented as s.e.m. of n≥3 experimental groups. *P<0.05, **P<0.01, ***P<0.001 (Student t-test).
