Figure 6: Model depicting the mechanisms of H3K4me3 loss in senescence.
From: Histone H3.3 and its proteolytically processed form drive a cellular senescence programme
The HUCA histone chaperone complex showing ASF1a/HIRA is depicted depositing H3.3, coupled to eviction of replication-dependent histone H3.1. Both JARID1A/1B-mediated demethylation and CTSL-mediated proteolytic processing of H3.3 tail act to prevent transcription of cell cycle-related genes via removal of H3K4me3. These processes may work together or independently to ensure the silencing of proliferation-promoting genes during cellular senescence.
