Figure 3: Loss of Med23 results in autoimmune symptoms.
From: The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity
(a) Percentage statistics for CD44, CD25 and CD69 expression in isolated T cells from the blood or indicated organs (kidney, n=3; blood and liver, n=4; lung, n=7; *P<0.05 and **P<0.01 by Student’s t-test; NS, no significance). (b) Mononuclear cell infiltration in the lung and liver of Med23−/− and WT mice (15- to 18-month-old) was visualized by haematoxylin and eosin staining (magnification, × 100 and × 400; scale bars, 100 μM). The anti-dsDNA IgG (c) or IFNγ concentration (d) in the serum of aged mice (15- to 18-month-old) was assessed by enzyme-linked immunosorbent assay (anti-dsDNA, n=4; IFNγ, n=3; *P<0.05 by Student’s t-test). Error bars indicate s.e.m. All results are representative of or combined from at least three independent experiments.
